![]() ![]() 3 Thus, the total burden of endophthalmitis is increasing substantially with thousands of cases occurring annually.Ĭurrently, microbial culture remains the gold standard for detecting organisms associated with endophthalmitis. 1 While the incidence rate of endophthalmitis following intravitreal injections is low, ranging in various studies from 0.01 to 0.1%, 1, 2 more than 6 million intravitreal injections were performed last year in the United States alone. Post-surgical endophthalmitis occurs following approximately 0.1 to 0.2% of cataract surgeries with substantial loss of vision in many cases. Presence of TTV at presentation was associated with a higher rate of secondary PPV (p=0.009) and retinal detachment (p=0.022).Įndophthalmitis is a serious sight-threatening condition. ![]() Torque teno virus (TTV) and Merkel cell polyomavirus (MCV) were detected by qPCR in 49% and 19% of cases, respectively. Higher baseline bacterial DNA loads of bacteria other than S.epidermidis detected by WGS were associated with worse month 1 and 3 visual acuity, while the S.epidermidis loads did not appear to influence outcomes. epidermidis endophthalmitis were no different than those of pathogen-negative cases, while the patients infected with other pathogens showed worse outcome. Month 1 and 3 visual acuities did not vary by pathogen-positive vs pathogen-negative cases as detected by either culture or WGS. WGS identified the cultured organism in 76% of culture-positive cases and identified potential pathogens in 33% of culture-negative cases. Twenty-four cases were culture-positive and 26 were culture-negative. A total of 50 patients (mean age 72, 52% male) were enrolled. ![]()
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